Романова Татьяна Алексеевна

ОБРАЗОВАНИЕ:

Ветеринарный врач, 1994, Красноярский Государственный Аграрный университет, Россия;

Кандидат биологических наук, 1998, Красноярский Государственный Аграрный университет, Россия;

Бизнес-менеджер, 2008, Стрэдфорский профессиональный институт (Stratford Career Institute), Вермонт, США.

1989 - 1994, Красноярский Государственный Аграрный университет, Россия;

1995 - 1998, Аспирантура, Красноярский Государственный Аграрный университет, Россия;

2001 - 2004, Докторантура, Институт вычислительного моделирования СО РАН, Красноярск, Россия;

2008 - 2008, Бизнес-менеджмент, Стрэдфорский профессиональный институт (Stratford Career Institute), Вермонт, США.

ПРОФЕССИОНАЛЬНАЯ ДЕЯТЕЛЬНОСТЬ:

1994 - 1996 (два года), ассистент кафедры, стажер-исследователь (морфология), Красноярский Государственный Аграрный университет, Красноярск, Россия;

1994 - 1996 (два года), ветеринарный врач (терапия/хирургия), Клиника для мелких домашних животных при Красноярском Государственном Аграрном университете, Красноярск, Россия;

1997 - 2001 (четыре года), старший преподаватель, доцент (биохимия),Красноярский Государственный Аграрный университет, Красноярск, Россия;

2001 - 2003 (два года) доцент (промышленная экология), Красноярский Государственный Технический университет, Красноярск, Россия;

2002 - 2004 (два года), доцент (компьютерное моделирование лекарств), Красноярский Государственный университет, Красноярск, Россия;

2003 - 2004 (один год), приглашенный исследователь, Нациолнальная лаборатория в г. Эймс (Ames National Laboratory, ISU), Эймс, Айова, США;

2003 - 2005 (два года), снс (биофизика), Международный научный центр исследований экстремальных состояний организма при Президиуме СО РАН, Красноярск, Россия;

2004 - 2008 (четыре года), снс (компьютерное моделирование/биофизика), Институт вычислительного моделирования СО РАН, Красноярск, Россия;

2005 - 2007 (два года), исследователь по гранту Японского Агенства Науки и Технологий (JST-CREST) в Лаборатории компьютерных исследований Научного центра Отделения науки и технологий корпорации Митсубиши-Химия, Исследовательский центра в г. Йокогама, Япония;

2008 - в настоящее время, основатель и президент компании North Concept, Inc., Токио, Япония;

2009 - в настоящее время, Менеджер Отдела Исследований и Международного сотрудничества, ТЦГО, Токио, Япония.

НАГРАДЫ, ЗВАНИЯ, ГРАНТЫ::

6-ой Конкурс-экспертиза научных проектов молодых ученых РАН, грант No 218, 1999 - 2002;

Участник-исполнитель гранта Российской государственной программы “Государстванная поддержка интеграции высшей школы и фундаментальной науки”, грант No D0204/1 направления 2.8, 2002;

Диплом и стипендия Губернатора Красноярского края для молодых талантливых ученых, в номинации "Докторанты", 2002;

Руководитель гранта Красноярского Краевого Фонда Науки, грант No 11F00544F, 2003;

Участник-исполнитель гранта Российской государственной программы “Государстванная поддержка интеграции высшей школы и фундаментальной науки”, грант No D3213 направления 2.8, 2003;

Руководитель гранта Лаврентьевского конкурса молодых ученых СО РАН, грантt No 4, 2003-2004.

СЕРТИФИКАТЫ, ЛИЦЕНЗИИ:

Доцент по специальности (биофизика), диплом No 001816, 2006.

Научные публикации

Books and reviews

Romanova T.A., Avramov P.V. The chemical bonding in a nanoobjects. Proteins and elementary carbon // Bulletin of Krasnoyarsk State University, chem., #3, p. 32 (2003);

Romanova T.A., Krasnov P.O., Kachin S.V., Avramov P.V., “Theory and application of computation modeling in chemistry. Nanostructures and biological molecules”, Krasnoyarsk State University (2002) (CD);

Ingevatkin E.V., Romanova T.A., Albrandt A.I., Savchenco A.A., Nefedov V.P. The modern conception of a participation of hsp proteins in induction of immune response // Proc. IXth Russian Symp. “The reconstruction of homeostasis”, Krasnoyarsk, Russia. V.1, pp. 54-59, (1998);

Romanova T.A., Еgorova A.B., Nefedov V.P., Mechanisms of Forming of “cross termotolerance” for effect of industrial xenobiotics (acrylamid) // The fundamental sciences for medicine (realities , priorities, outlooks), Krasnoyarsk, Krasnoyarsk State Polytechnic University, 424 p., pp. 23 –37 (1998).

Contributions to scientific journals

Romanova T.A., Krasnov P.O. Ab initio and post-ab initio quantum chemical study of the heme spin states in electron transfer reactions // Chem. Phys. Lett. V. 420, pp. 281-285 (2006).

Romanova T.A., Morgulis I.I., Krasnov P.O., Avramov P.V., Hypothesis of hemoprotein sensor confirmed by ab initio quantum-chemical calculation // Internet Electronic J. Mol. Des. V. 4, 5, pp. 309-315 (2005);

Romanova T.A., Avramov P.V. The structure of valence band of the cytochrome-c-oxidase active sites of cluster model // Journal of Structural Chemistry, V. 46, 2, pp. 351 - 355 (2005);

Krasnov P.O., Kuzubov A.A., Romanova T.A., Avramov P.V. Effect of the heterocyclic ligand in iron-porphirinate complex on the strength of the bond between iron and CO molecule // Russian Journal of Coordination Chemistry, V 30, 9, pp. 634-638 (2004);

Romanova T.A., Avramov P.V., A Choice of quantum-chemical methods for calculation of electron affinity of amino acids // J. Biomedical chemistry (in Russian), Addit. Iss. 1, pp. 56-61 (2004);

Romanova T.A., Krasnov P.O., Kuzubov A.A., Avramov P.V., Comparative quantum-chemical analysis of electronic structure of valence bands of cluster models of active sites of cytohromes f and c // Journal of Structural Chemistry (in Russian), V. 45, 2, pp. 199-205 (2004);

Romanova T.A., Kravchenko O.V., Morgulis I.I., Kuzubov A.A., Krasnov P.O., Avramov P.V., Confirmation of a hypothesis of hemoprotein sensor by ab initio method of quantum chemistry // Russian Journal of Coordination Chemistry, V 30, 6 (2004);

Romanova T.A., Krasnov P.O., Kuzubov A.A., Avramov P.V., The Role of Histidine in the Ligand-Bonding Capacity of the Hemoglobin Heme // Russian Journal of Bioorganic Chemistry, V. 30, 6, pp. 124-128 (2004);

Romanova T.A., Kuzubov A.A., Krasnov P.O., Avramov P.V. Structure and electronic state of hem with different ligands // Biophysics (in Russian). V. 48, 4, pp.618-627 (2003);

Romanova T.A., Avramov P.V. Nature of highest occupied orbital of aminoacids of active sites of heme proteins // DAN (in Russian). V. 383, 1, 116-119 (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Electronic structure of hem complex of hemoglobine with nitric oxide and dynamics of atomic base under physiological temperature // Questions of medical chemistry (in Russian). V. 47, pp. 308-315 (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Modification of hem electronic structure induced by complex formation with nitric oxide and the atomic backbone dynamics at room temperature // DAN BioChem and BioPhys (in Russian). V. 380, pp. 1-3, (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Selection of cluster models for electronic structure calculations and dynamics of atomic base of hem-containing proteins by QM/MM and ONIUM methods // Electronic J “Studied in Russia”, 91, pp. 1009-1016, http://zhurnal.ape.relarn.ru/articles/2001/091.pdf (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Electronic structure and dynamics of atomic base of hem complexes of hemoglobin with ligands under physiological temperature // Electronic Journal “Studied in Russia”, 70, pp. 781-791, http://zhurnal.ape.relarn.ru/articles/2001/070.pdf (2001);

Romanova T.A. Implication of cytohrome P450 – dependent system biotransformation in interpretation of toxic effects of the acrilamide // Questions of medical chemistry (in Russian). V. 46, #. 2, pp. 140-149 (2000);

Nefedov V. P., Romanova T.A., Roupenko А.P., Еgorova A.B. The modulation of reactions of oxidative phosphorilation in hepatocites as a mechanism of “cross termotolerance // Doklady, Russian Academy of Sciences, Physiol (in Russian). V. 368, 2, pp. 280-283, (1999);

Romanova T.A., Еgorova A.B., Ivanov V.V., Nefedov V.P. Heat shock modeling of cytotoxic of xenobiotics in vivo // Bulletin of experimental biology and medicine (in Russian). V. 126, 11, pp. 546 – 547 (1998).

Abstracts of contrubutions to conferencies

Satoshi Yokojima, Tatiana Romanova, Akinori Murakami, Shusaku Daikoku,Osamu Kanie, Shinichiro Nakamura, Mechanism of glycosidic bond cleavage in collision induced dissociation II:quantum chemical study on structure of oligosaccharide,(2008);

Shinoda K., Romanova T.A., Gao Q., Yokojima S., Murakami A., Shen J.-W., Kanie O., Nakamura Sh. MD simulation of the sugar chain dynamic // 21th Molecular Simulation Forum Nov 26 – 28, Kanazawa, Ishikawa, Japan (2007);

Murakami A., Romanova T., Yokojima S., Gao Q., Daikoku Sh., Kanie O., Nakamura Sh. The Anomeric Stability of Fuc-Gal // 27th Japanese carbohydrate symposium, Aug 1-3, 2007, Fukuoka, Japan, p. 68 (2007);

Romanova T., Murakami A., Yokojima S., Shen J.-W., Daikoku Sh, Kanie O., Nakamura Sh. Mechanism of the Glicosidic Bond Clevage of alfa-Fuc-(1-2)-beta-Gal-(1-1)-Octyl and beta-Fuc-(1-2)-beta-Gal-(1-1)-Octyl in Collision Induced Dissociation // 27th Japanese carbohydrate symposium, Aug 1-3, 2007, Fukuoka, Japan, p. 142 (2007);

Romanova T.A., Lee J., Vysotski E.S. The study of bioluminescence mechanism of Ca2+-regulated photoproteins in the cluster model of active site by semiempirical CAS-CI method // 1st NAREGI International Nanoscience Conf., June 14-18, Nara, Japan, p. 196 (2005);

Romanova T. A. DFT study of the electronic structure and spin state of cytohrome P-450 iron atom on stages monoxygenase reaction // Information technology in chemistry, physics and biology (IVTN-2005), Moscow, (2005);

Romanova T.A., Vysotski E.S. The semiempirical CAS-CI study of bioluminescence mechanism of Ca2+-regulated photoproteins // Information technology in chemistry, physics and biology (IVTN-2005), Moscow, (2005);

Romanova T. A., Krasnov P.O., Kuzubov A.A., Avramov P.V. Selection of cluster models for electronic structure calculations of cytohromes // Information technology in chemistry, physics and biology (IVTN-2004), Moscow, (2004);

Krasnov P.O., Romanova T.A., Avramov P.V., Spin States of Fe-Porphirin in Electron Transfer Process // Midwest MWTCC-36, June 17 - 19, East Lansing, MI, USA, p.79 (2004);

Romanova T.A., Avramov P.V. Structure of Valent Band of Clusters Model of Active Sites of Cytochrome c Oxidase MWTCC-36, June 17 - 19, East Lansing, MI, USA, p.122 (2004);

Krasnov P.O., Kuzubov A.A., Romanova T.A., Avramov P.V. DFT study of the influence of heterocyclic ligands at the heme proximal site on the strength of chemical bonding with CO at the distal site // IXth International conference on chemistry of porphyrins and their analogues, September 8-12, 2003, Suzdal, Russia, p. 48 (2003);

Avramov P.V., Yakobson B.I., Scuceria G.E., Romanova T.A. Interaction of Low-Energy Protons with Hollow Carbon and Fluorinated Carbon Nanostructures // IWFAC-2003, June 30 – July 4 2003, St. Petersburg, Russia, p. 22 (2003);

Avramov P.V., Yakobson B.I., Scuceria G.E., Romanova T.A. Interaction of Low-Energy Protons with Hollow Carbon and Fluorinated Carbon Nanostructures: Quantum Chemical and Molecular Dynamic Study // Xth APAM Seminar “Nanoscience and Technology”, June 2-6 2003, Novosibirsk, Russia, pp. 304-305 (2003);

Avramov P.V., Yakobson B.I., Scuceria G.E., Romanova T.A. Electronic Structure of 1D Carbon Nanostructures with Defects: An ab initio Study // Xth APAM Seminar “Nanoscience and Technology”, June 2-6 2003, Novosibirsk, Russia, pp. 326-327 (2003);

Romanova T., Krasnov P., Avramov P. Electronic structure of nanoclusters of active sites of hemoproteins // XVIth International Winterschool on electronic properties of novel materials. Molecular Nanoclusters, 2-9 Marth 2002, Kirchberg, Tirol, Austria, p. 74 (2002);

Romanova T. A., Krasnov P.O., Kuzubov A.A., Avramov P.V. Selection of cluster models for electronic structure calculations of cytohromes // Information technology in chemistry, physics and biology (IVTN-2002), Moscow, (2002);

Romanova T., Krasnov P. Modification of electronic structure of heme under formation of complex with nitric oxide and dynamics of atomic base under physiological temperature // 4th International conference on biological physics, July 30-August 3, 2001, Kyoto, Japan, p. 113 (2001);

Remmel N., Maznyak O., Romanova T., Kratasyuk V. Bioluminescent assay of lipid peroxidation products during perfusion of rat liver // 4th International conference on biological physics, July 30-August 3, 2001, Kyoto, Japan, p. 157 (2001);

Romanova T., Fedorov A. The sex differences in dynamics of liver vascular resistance and energy exchange at rats liver perfusion in situ after heat shock in vivo // 4th International conference on biological physics, July 30-August 3, 2001, Kyoto, Japan, p. 110 (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Selection of cluster models for electronic structure calculations and dynamics of atomic base of hem-containing proteins by QM/MM and ONIOM methods // “Computer assistance for chemical research-2001”, Moscow (2001);

Romanova T.A., Krasnov P.O., Avramov P.V. Electronic structure and dynamics of atomic base of hem complexes of hemoglobin with ligands under physiological temperature // “Computer assistance for chemical research-2001”, Moscow (2001);

Romanova T.A. Roupenko A.P. A functionality activity of rat liver at rehabilitation period after heat shock // I.P. Pavlov Intern. Congress “Functional Mechanisms of Visceral Systems”, Sep. 23-25, St.-Petersburg, Russia, p. 314 (1999);

Romanova T.A. A decreasing of functional activity of some metalloproteins as a possible mechanism of cell steadiness for oxidative stress // IInd Congress of Russia Biophysics, Moscow. V.1, pp. 208-209 (1999);

Ingevatkin E.V., Romanova T.A., Savchenco A.A., Nefedov V.P. Modulation of functional activity of rat perfusing liver after short-term hyperthermia // IInd Congress of Russia Biophysics, Moscow. V.1, pp. 196-197 (1999);

Romanova T.A., Nefedov V.P. The modulation of reactions of oxidative phosphorilation in hepatocites as possible mechanism of “cross thermotolerance” // 17th Russian Congress of Physiologists, Rostov on Don, Russia, p. 106 (1998);

Romanova T.A., Egorova A.B., Nefedov V.P. The change of cytotoxic effects of xenobiotics after hyperthermia period // IIIrd Congress of Physiologists of Siberia and Far East, Novosibirsk, Russia, p. 193 (1997).

Other papers

Avramov P.V., Romanova T.A. Ovchinnikov S.G., HyperChem Program and specification. Published in the book Quantum-chemical and molecular-dynamics simulation of structure and properties of carbon nanostructures. Publishing House of Siberian Brunch of Russian Academy of Sciences, (multimedia CD-book) (2000);

Romanova T.A. Role of preliminary induction of microsomal oxidases system for realization of toxic effects of industrial xenobiotik acrylamide // Bulletin of Krasnoyarsk State Agriculture University, # 3, pp. 110-113 (1999);

Romanova T.A. Cell mechanisms of cross-thermotolerance to chemical ecologicaly dengerous factor akrilamid. Comprehensive Summary of the candidate dissertation, Krasnoyarsk State Agricultural University, Krasnoyarsk, 22 pp. (1998).

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