Научная тема: «СТРУКТУРНЫЕ И ДИНАМИЧЕСКИЕ АСПЕКТЫ ФУНКЦИОНИРОВАНИЯ ДНК-N-ГЛИКОЗИЛАЗ В ПРОЦЕССЕ ЭКСЦИЗИОННОЙ РЕПАРАЦИИ ОСНОВАНИЙ ДНК»
Специальность: 03.00.04
Год: 2008
Отрасль науки: Биологические науки
Список опубликованных работ
1. Zharkov D.O., Rosenquist T.A., Gerchman S.E., Grollman A.P. (2000) Substrate

specificity and reaction mechanism of murine 8-oxoguanine-DNA glycosylase. J. Biol.

Chem., 275, p. 28607–28617.

2. Zharkov D.O., Golan G., Gilboa R., Fernandes A.S., Gerchman S.E., Kycia J.H.,

Rieger R.A., Grollman A.P., Shoham G. (2002) Structural analysis of an Escherichia

coli endonuclease VIII covalent reaction intermediate. EMBO J., 21, p. 789–800.

3. Gilboa R., Zharkov D.O., Golan G., Fernandes A.S., Gerchman S.E., Matz E.,

Kycia J.H., Grollman A.P., Shoham G. (2002) Structure of formamidopyrimidine-DNA

glycosylase covalently complexed to DNA. J. Biol. Chem., 277, p. 19811–19816.

4. Zharkov D.O., Rosenquist T.A. (2002) Inactivation of mammalian 8-oxoguanine-DNA

glycosylase by cadmium(II): Implications for cadmium genotoxicity. DNA Repair, 1,

p. 661–670.

5. Zharkov D.O., Grollman A.P. (2002) Combining structural and bioinformatics methods

for the analysis of functionally important residues in DNA glycosylases. Free Radic.

Biol. Med., 32, p. 1254–1263.

6. Minetti C.A.S.A., Remeta D.P., Zharkov D.O., Plum G.E., Johnson F., Grollman A.P.,

Breslauer K.J. (2003) Energetics of lesion recognition by a DNA repair protein:

Thermodynamic characterization of formamidopyrimidine-glycosylase (Fpg)

interactions with damaged DNA duplexes. J. Mol. Biol., 328, p. 1047–1060.

7. Rosenquist T.A., Zaika E., Fernandes A.S., Zharkov D.O., Miller H., Grollman A.P.

(2003) The novel DNA glycosylase, NEIL1, protects mammalian cells from radiationmediated

cell death. DNA Repair, 2, p. 581–591.

8. Zharkov D.O., Shoham G., Grollman A.P. (2003) Structural characterization of the Fpg

family of DNA glycosylases. DNA Repair, 2, p. 839–862.

9. Conlon K.A., Zharkov D.O., Berrios M. (2003) Immunofluorescent localization of the

murine 8-oxoguanine DNA glycosylase (mOGG1) in cells growing under normal and

nutrient deprivation conditions. DNA Repair, 2, p. 1337–1352.

10. Zharkov D.O., Ishchenko A.A., Douglas K.T., Nevinsky G.A. (2003) Recognition of

damaged DNA by Escherichia coli Fpg protein: Insights from structural and kinetic

data. Mutat. Res., 531, p. 141–156.

11. Zaika E.I., Perlow R.A., Matz E., Broyde S., Gilboa R., Grollman A.P., Zharkov D.O.

(2004) Substrate discrimination by formamidopyrimidine-DNA glycosylase: A

mutational analysis. J. Biol. Chem., 279, p. 4849–4861.

12. Koval V.V., Kuznetsov N.A., Zharkov D.O., Ishchenko A.A., Douglas K.T.,

Nevinsky G.A., Fedorova O.S. (2004) Pre-steady-state kinetics shows differences in

processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA

glycosylase. Nucleic Acids Res., 32, p. 926–935.

13. Golan G., Zharkov D.O., Fernandes A.S., Zaika E., Kycia J.H., Wawrzak Z.,

Grollman A.P., Shoham G. (2004) Crystallization and preliminary crystallographic

analysis of endonuclease VIII in its uncomplexed form. Acta Crystallogr., D60,

p. 1476–1480.

14. Conlon K.A., Zharkov D.O., Berrios M. (2004) Cell cycle regulation of the murine 8-

oxoguanine DNA glycosylase (mOGG1): mOGG1 associates with microtubules during

interphase and mitosis. DNA Repair, 3, p. 1601–1615.

15. Perlow-Poehnelt R.A., Zharkov D.O., Grollman A.P., Broyde S. (2004) Substrate

discrimination by formamidopyrimidine-DNA glycosylase: Distinguishing interactions

within the active site. Biochemistry, 43, p. 16092–16105.

16. Zharkov D.O. Predicting functional residues in DNA glycosylases by analysis of

structure and conservation. In: Practical Bioinformatics, Bujnicki J.N., Ed. Springer-

Verlag: 2004. P. 243–261.

17. Conlon K.A., Miller H., Rosenquist T.A., Zharkov D.O., Berrios M. (2005) The murine

DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase β bind microtubules

in situ and in vitro. DNA Repair, 4, p. 419–431.

18. Parsons J.L., Zharkov D.O., Dianov G.L. (2005) NEIL1 excises 8-oxoguanine located

near a DNA single strand break. Nucleic Acids Res., 33, p. 4849–4856.

19. Golan G., Zharkov D.O., Feinberg H., Fernandes A.S., Zaika E.I., Kycia J.H.,

Grollman A.P., Shoham G. (2005) Structure of the uncomplexed DNA repair enzyme

endonuclease VIII indicates significant interdomain flexibility. Nucleic Acids Res., 33,

p. 5006–5016.

20. Zharkov D.O., Grollman A.P. (2005) The DNA trackwalkers: Principles of lesion

search and recognition by DNA glycosylases. Mutat. Res., 577, p. 24–54.

21. Golan G., Zharkov D.O., Grollman A.P., Dodson M.L., McCullough A.K., Lloyd R.S.,

Shoham G. (2006) Structure of T4 pyrimidine dimer glycosylase in a reduced imine

covalent complex with abasic site-containing DNA. J. Mol. Biol., 362, p. 241–258.

22. Kropachev K.Y., Zharkov D.O., Grollman A.P. (2006) The catalytic mechanism of

Escherichia coli endonuclease VIII: Roles of the intercalation loop and the zinc finger.

Biochemistry, 45, p. 12039–12049.

23. Кирпота О.О., Жарков Д.О., Бунева В.Н., Невинский Г.А. (2006) Взаимодействие

8-оксогуанин-ДНК-гликозилазы человека с одно- и двухцепочечными ДНК.

Молекуляр. биология, 40, с. 1055–1063.

24. Zharkov D.O., Golan G., Shoham G., Kropachev K.Y., Grollman A.P.,

Kuznetsov N.A., Koval V.V., Douglas K.T., Nevinsky G.A., Fedorova O.S. (2006).

Structural dynamics of Escherichia coli endonuclease VIII.//Сборник трудов

международной конференции «Физико-химическая биология», посвященной 80-

летию академика Д.Г. Кнорре. — Новосибирск: АРТА. — С. 29-30.

25. Kuznetsov N.A., Koval V.V., Zharkov D.O., Nevinsky G.A., Douglas K.T.,

Fedorova O.S. (2007) Pre-steady-state kinetic study of substrate specificity of

Escherichia coli formamidopyrimidine-DNA glycosylase. Biochemistry, 46, p. 424–

435.

26. Старостин К.В., Ищенко А.А., Жарков Д.О., Бунева В.Н., Невинский Г.А. (2007)

Взаимодействие ферментов репарации про- и эукариот с

олигодезоксирибонуклеотидами, содержащими кластерные повреждения.

Молекуляр. биология, 41, с. 112–120.

27. Kuznetsov N.A., Zharkov D.O., Fedorova O.S. (2007) Conformational dynamics of

interactions of Escherichia coli endonuclease VIII with DNA substrates. J. Biomol.

Struct. Dyn., 24, p. 615-616.

28. Жарков Д.О. (2007) Структура и конформационная динамика гликозилаз

эксцизионной репарации оснований ДНК. Молекуляр. биология, 41, с. 772–786.