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Халдояниди София Константиновна

Научная тема: « РОЛЬ ГИАЛУРОНОВОЙ КИСЛОТЫ В РЕГУЛЯЦИИ ИММУНО-И МИЕЛОПОЭЗА »

Научная биография   « Халдояниди София Константиновна »

Членство в Российской Академии Естествознания

Специальность: 14.03.09

Год: 2011

Отрасль науки: Медицинские науки

Основные научные положения, сформулированные автором на основании проведенных исследований:

  1. Гиалуроновая кислота является элементом гемопоэтического микроокружения, регулирующим продукцию цитокинов и экспрессию адгезивных молекул в клетках костного мозга путем активации CD44.
  2. Гиалуроновая кислота регулирует рекрутирование ГСК, но не их мобилизацию.
  3. Гиалуроновая кислота необходима для дифференцировки ЭСК в мезодермальном направлении и генерирования гемопоэтических клеток.

Список опубликованных работ

1. Khaldoyanidi S., Achtnich, M., Hehlmann, Zцller M. Expression of CD44 variant isoform in peripheral blood leukocytes in malignant lymphoma and leukemia: inverse correlation between expression and tumor progression // Leukemia Research. – 1996. – Vol.20. – Р. 839-851.

2. Khaldoyanidi S.K., Denzel A., Zцller M. Requirement for CD44 in proliferation and homing of hematopoietic precursor cells // J. of Leukocyte Biol. – 1996. – Vol.60. – P.579-592.

3. Khaldoyanidi, S.K., Schnabel D., Fцhr N., Zцller M. Functional activity of CD44 isoforms in haemopoiesis of the rat // British J. of Haematol. – 1997. – Vol. 96. – P. 31-45.

4. Moll J., Khaldoianidi S.K., Sleeman J.P., Achtnich M., Preuss I., Ponta H., Herrlich P. Two different functions for CD44 proteins in human myelopoie-sis // J. Clin. Invest. – 1998. – Vol. 102. – P. 1024-1034.

5. Khaldoyanidi S.K., Moll J., Karakhanova S.S., Herrlich P., Ponta H. Hyaluronate-enhanced hematopoiesis: Tow different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages // Blood – 1999. – Vol. 94. – P. 940-949.

6. Roesel M., Khaldoyanidi S., Zawadzki V., Zoeller M. Involvement of CD44 variant isoform v10 in progenitor cell adhesion and maturation // Exp. Hema-tol. – 1999. – Vol. 27. – P. 698-711.

7. Muller-Sieburg C., Deryugina E., Khaldoyanidi S., O’Rourke A. Tissue- and epitope-specific mechanisms account for the diverse effect of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro // Blood Cells, Molecules, and Diseases – 2000. – Vol. 26. – P. 291-302.

8. Khaldoyanidi S., Sikora L., Orlovskaya I., Matrosova V., Kozlov V., Sriramarao P. Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells // Blood – 2001. – Vol. 98. – P. 303-312.

9. Khaldoyanidi S., Karakhanova S., Sleeman J., Herrlich P., Ponta H. CD44 variant specific antibodies trigger hemopoiesis by selective release of cyto-kines from bone marrow macrophages // Blood. – 2002. – Vol. 99. – P. 3955-3961.

10. Khaldoyanidi S.K., Glinsky V.V., Sikora L., Glinskii A.B., Mossine V.V., Glinsky G.V., Sriramarao P. MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions // The Journal of Biological Chemistry – 2003. – Vol. 278. – P. 4127-4134.

11. Khaldoyanidi S., Sikora L., Rothenberg M., Broide D., Sriramarao P. Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen // Blood – 2003. – Vol. 101. P. 863-868.

12. Matrosova V., Orlovskaya I., Serobyan N., Khaldoyanidi S. Hyaluronic acid facilitates recovery of hematopoiesis impaired by 5-fluouracil administration // Stem Cells – 2004. – Vol. 22. P. 544-555.

13. Serobyan N., Schraufstatter I. U., Strongin A., Khaldoyanidi S.K. Nicotinic acetylcholine receptor-mediated activation of endothelial cells results in the arrest of hematopoietic progenitor cells on endothelium // British J. of Hae-matol. – 2005. – Vol. 129. – P. 257-265.

14. Serobyan N., Orlovskaya I., Kozlov V., Khaldoyanidi S.K. Exposure to nicotine during gestation interferes with the colonization of fetal bone marrow by hematopoietic stem/progenitor cells // Stem Cell and Development – 2005. – Vol. 14. – P. 81-91.

15. Matrosova V., Orlovskaya I., Serobyan N., McClelland M., Khaldoyanidi S. Hyaluronan facilitates recovery of hematopoiesis after therapy-induced mye-losuppression // In: Hyaluronan, structure, metabolism, biological activities, therapeutic applications. Editors: E. Balazs and V. Hascall. – 2005. – Vol. II. – P. 813-820.

16. Mueller F.-J., Serobyan N., Schraufstatter I. U., DiScipio R., Loring J. F., Snyder E.Y., Khaldoyanidi S.K. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by in-tegrins // Stem Cells – 2006. – Vol. 24. – P. 2367-2372.

17. Wimmer A., Khaldoyanidi S., Judex M., Serobyan N., DiScipio R.G., Schraufstatter I.U. PARC/CCL18 stimulates hematopoiesis in long-term bone marrow cultures through its effect on accessory cells // Blood – 2006. – Vol. 108. – P. 3722-3729.

18. Serobyan N., Jagannathan S., Orlovskaya I., Schraufstatter I., Loring J., Skok M., Khaldoyanidi S. The Cholinergic System is involved in Regulation of the Development of the Hematopoietic System //Life Sciences. – 2007. – Vol. 80. – P. 2352-2360.

19. Топоркова Л.Б., Халдояниди С.К., Орловская И.А. Механизмы регуляции самоподдержания гемопоэтической стволовой клетки // Успехи современной биологии – 2008. – Т. 128. – С. 458-466.

20. Orlovskaya I., Schraufstatter I., Loring J., Khaldoyanidi S. Hematopoietic differentiation of embryonic stem cells // Methods – 2008. – Vol. 45. – P. 159-167.

21. Khaldoyanidi S. Directing stem cell homing // Cell Stem Cell – 2008. – Vol. 2. – P. 198-200.

22. Schraufstatter I.U., Serobyan N., Loring J., Khaldoyanidi S.K. Hyaluronan is required for generation of hematopoietic cells // J. of Stem Cells – 2010. – Vol. 5. – P. 9-21.

23. Schraufstatter I., Serobyan N., DiScipio R., Feofanova N., Orlovskaya I., Khaldoyanidi S. Hyaluronan Stimulates Mobilization of Mature Hematopoie-tic Cells but Not Hematopoietic Progenitors // J. of Stem Cells – 2009. – Vol. 4. – P. 191-202.

24. Mueller B.M., Schraufstatter I.U., Goncharova V., Povaliy T., Khaldoyanidi S.K. Hyaluronan inhibits postchemotherapy tumor re-growth in a colon carcinoma xenograft model // Molecular Сancer Therapeutics – 2010. – Vol. 9. – P. 3024-3032.

25. Omelyanchuk N., Orlovskaya I.A., Schraufstatter I.U., Khaldoyanidi S.K. Key players in the gene networks guiding ESCs toward mesoderm // J. of Stem Cells – 2009. – Vol. 4. – P. 147-160.

26. Khaldoianidi S.K., Karakhanova S.S., Herrlich P., Ponta H., Moll J. Hyaluronic acid stimulates hemopoiesis in vitro via upregulation of interleukin 6 production by macrophages. 10th Symposium on Molecular Biology of He-matopoiesis // In: Acta Haematologica – 1997. – Vol. 98 (suppl. 1). – P.79.

27. Khaldoiandi S.K., Karakhanova S., Moll J., Herrlich, P., Ponta H. Hyaluronic acid stimulates hemopoiesis in vitro. XIX Symposium of the International Association for Comparative Research on Leukemia and Pelated Diseases // In: J. of Molecular Medicine. – 1997. – Vol. 75. – P. B206.

28. Khaldoyanidi S.K., Broide D.H., Sriramarao P. Comparison of hematopoiesis in bone marrow of allergen challenged and IL-5 transgenic mice. American Academy of Allergy, Asthma and Immunology 56th Annual Meeting, San Diego, California, USA // In: J. of Allergy and Clin. Immunol. - 1999. - Vol. 105. - P. S88.

29. Khaldoyanidi S.K., Burger J.A., Kipps T.J., Sriramarao P. CD44 and L-selectin support rolling of chronic lymphocytic leukemia cells on endothelial cells in vitro. Annual Scientific Meeting of the American Society of Hema-tology, 1999, New Orleans, USA // In: Blood - 1999. - Vol. 94, No 10 (suppl. 1). - p.546a.

30. Khaldoyanidi S., Sleeman J., Herrlich P., Ponta H. Monoclonal antibody to CD44 splice variants enhances hematopoiesis in LTBMC via up-regulation of GM-CSF and IL-6. 13th International Symposium on Molecular Biology of Hematopoiesis and Treatment of Leukemia, Lymphoma & Cancer, New York, USA // In: Acta Haematologica. - 2000. - Vol. 103(suppl 1). - P. 19.

31. Khaldoyanidi S. Hyaluronan enhances hematopoietic recovery after 5-FU via up-regulation of cytokine production by bone marrow macrophages. Annual Scientific Meeting of the American Society of Hematology, 2001, Orlando, USA // In: Blood. - 2001. - Vol. 98, No 11. - p.297a.

32. Orlovskaya I.A., Matrosova V.Y., McClelland M.1, Khaldoyanidi S.K. Hyaluronan facilitates recovery of ablated hematopoiesis via activation of cytokine production by bone marrow macrophages. 32nd Annual Meeting of the International Society for Experimental Hematology, Paris, France, 2003. // In: Experimental Hematology, Vol. 31, No. 7, Supplement 1- p. 152.

33. Khaldoyanidi S.K. The CD44/HA pathway regulates the hematopoiesis-supportive function of the bone marrow microenvironment. 33 rd Annual Scientific meeting of the International Society for Experimental Hematology, New Orleans, 2004. USA // In: Experimental Hematology, Vol. 32, No. 7, Supplement 1 - p.55.

34. Khaldoyanidi S., Schraufstatter I. CCL18/PARC is a novel factor that regulates hematopoiesis-supportive function of bone marrow microenvironmental niche. 34th Annual Scientific meeting of the International Society for Experimental Hematology, 2005, Glasgow, Scotland. // In: Experimental Hematology, Vol 33, No. 7, Supplement 1 - p. 126.

35. Serobyan N., Khaldoyanidi S. The role of hyaluronan in recruitment and retention of HSC in the hematopoietic niche. 35th Annual Scientific meeting of the International Society for Experimental Hematology, Minneapolis, 2006. USA // In: Experimental Hematology, Vol. 34, No 9, Supplement 1 - p. 62.

36. Serobyan N., Khaldoyanidi S. 3D-parallel laminar flow chamber: A novel tool to study homing of human hematopoietic stem cells (HSC). 35th Annual Scientific meeting of the International Society for Experimental Hematology, Minneapolis, 2006. USA // In: Experimental Hematology, Vol. 34, No 9, Supplement 1 - p. 84.

37. Schraufstatter I., Orlovskaya I., Loring J., Khaldoyanidi S. The Cholinergic System is involved in Regulation of the Development of the Hematopoietic System. 37th Annual Scientific meeting of the International Society for Experimental Hematology, Boston, 2008. USA // In: Experimental Hematology, Vol. 36, No 7, Supplement 1– p.S13.

38. Schraufstatter I., Loring J., Khaldoyanidi S. Endogenously produced hyaluronan is required for mesodermal differentiation of human embryonic stem cells. 38th Annual Scientific meeting of the International Society for Experimental Hematology, 2009, Athens, Greece. // In: Experimental Hematology, Vol. 37, No 9, Supplement 1 – p. S58.

39. Schraufstatter I.U., DiScipio R.G., Khaldoyanidi S.K. Activation of nonneural acetylcholine receptors attenuates anaphylatoxin-mediated migration of mesenchymal stem cells. 38th Annual Scientific meeting of the International Society for Experimental Hematology, 2009, Athens, Greece. // In: Experimental Hematology, Vol. 37, No 9, Supplement 1 – p. S58.

40. Goncharova V., Schraufstatter I., Orlovskaya I., Khaldoyanidi S. Hyaluronan associated with the bone marrow hematopoietic microenvironment is required for the recruitment of circulating hematopoietic stem cells into the bone marrow. 39th Annual Scientific meeting of the International Society for Experimental Hematology, 2010, Melbourne, Australia. // In: Experimental Hematology, Vol. 38, No 9, Supplement 1, – p. S32.

41. Valentina Goncharova, Shinji Iizuka, Ingrid Schraufstatter, Irina Orlovskaya, Yu Yamaguchi and Sophia Khaldoyanidi. Hyaluronan associated with the bone marrow hematopoietic microenvironment is required for the recruitment and retention of hematopoietic stem and progenitor cells in the bone marrow. Annual Scientific Meeting of the American Society of Hematology, 2010, Orlando, USA // In: Blood. Vol. 116, No 21. – p.1072.

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